Study of Liver Cancer in Dogs

Liver cancer in dogs canine trial study

First in Dog Oncology Trial utilizing Radioembolization Eye90 microspheres™ Advanced Treatment Study (FIDO TREATS)

ABK Biomedical and our partners at The College of Veterinary Medicine, University of Missouri, are recruiting patients for a clinical trial evaluating the effectiveness of Y-90 radioembolization for the treatment of liver tumors in dogs. 

Study Information

Study Information

Terms of The Study

A full screening will be performed prior to enrollment

Pet owner must be willing to transport their dog to and from the treatment center in Columbia, MO

Treatment includes Y90 radioembolization of hepatocellular (liver) cancer using novel, radiopaque Eye90 microspheres™

Treatment will be followed by examination and imaging at 3 months and 6 months

All dogs will receive radioembolization and a subset will be considered for subsequent, post-radioembolization partial liver resection

Participation may require a total of up to 5-visits over 6-months

Study benefits include:

•Radioembolization and surgical resection (if eligible)
•Follow-up physical exams and CT imaging at 3- and 6- months
•The opportunity to contribute to development of an important cancer therapy

Eligibility Criteria

Any type of dog diagnosed with a primary liver tumor is potentially eligible for study entry.

Candidates must also meet all the following requirements:

  • Signed informed consent from the client prior to any study-related evaluation
  • Be neutered or spayed
  • At least one tumor must be great or equal to 3cm diameter,  with no more than 3 tumors total
  • Be a minimum of 12 kgs (26.4lb)
  • Be more than 1 year old
  • Have a reasonable life expectancy of more than 3 months without treatment
  • Have pathology confirmed HCC and no other diseases or behavioral conditions that would interfere with study conduct

Background and Rationale

Radiation therapy uses high-energy radiation to shrink tumors and kill cancer cells. The radiation is intended to damage the DNA of the cancer cells beyond repair so that they stop dividing or die. Radioembolization with Y-90 is an advanced form of radiation therapy that delivers high-dose radiation with precision, enabling precise targeting of a tumor with minimal damage to nearby healthy tissue.

Y-90 has been used to successfully treat liver tumors in over 100,000 human patients.  Studies have revealed that Y-90 is well-tolerated by the patient, results in minimal complications or side effects, maintains or improves the quality of life, and results in equivalent survival times when compared to surgery for patients with operable tumors.

Study Design

This is a two-arm prospective study. At least 6 dog patients are planned for enrollment. 

Arm 1: Eye90 microspheres™

Arm 2: Eye90 microspheres™ plus partial-liver surgical resection

Eligible patients will be treated once with Y-90 under a protocol consistent with the quality assurance practices of The College of Veterinary Medicine, University of Missouri.

Further Information

If you have additional questions about this study please contact the Principal Investigator at the address below, or click the link to send an Email:

Jeffrey N. Bryan, DVM
Professor of Oncology

Veterinary Medicine & Surgery
University of Missouri
Columbia, MO  65211

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