Dr. E. Courtney Henry, MD Anderson Cancer Center

American Association of Physicists in Medicine Annual Meeting 2022
“Best in Physics”

• Potential benefits of Eye90 microspheres Precision Dosimetry™ include reduced partial volume effects and respiratory motion artifacts, improved visualization of dose distribution, and accurate quantification of dose heterogeneity.
• Post-treatment CT imaging of radiopaque microspheres provides the means to perform precision dosimetry and extract more accurate absorbed dose metrics.
• The strong positive correlation between radiopaque microspheres and CT-based dosimetry may help physicians with dose-response relationships and improve future patient outcomes.

Robert J. Abraham MD, Dalhousie University

Society of Interventional Radiology Annual Meeting 2022

• Eye90 microspheres® are in clinical development and are the only imageable Y90 microspheres imageable using X-ray-based imaging technologies.
• CT-based dosimetry depicts dose heterogeneity with increased accuracy relative to PET-based dosimetry.
• This approach to dosimetry could provide clinicians with an opportunity to enhance their understanding of the dose-response relationship and improve patient outcomes.
• The First-in-Human study with Eye90 microspheres® for mCRC and HCC was initiated November 2021 in Auckland, NZ.

Robert J. Abraham MD, Dalhousie University

Society of Interventional Radiology Annual Meeting 2022

• Eye90 microspheres® is being evaluated in a First-in-Dog HCC Study in partnership with The University of Missouri College of Veterinary Medicine.
• Here, we describe a case study that evaluated tumor response after Eye90 microspheres administration in a dog patient with HCC.
• Significant anti-tumor response was noted after six weeks, and the dog underwent a successful left lobectomy.
• This case shows Eye90 microspheres treatment resulted in a beneficial tumor response, the ability to assess tumor targeting and coverage on CT, and inherent radiopacity correlated well with PET-based radioactivity and tissue histology.

Robert J. Abraham MD, Dalhousie University

Global Embolization Symposium & Technologies Annual Meeting 2022

• It is a known challenge to evaluate Y90 tumor microspheres deposition in vivo.
• ABK Biomedical developed a standardized in vitro model, in partnership with NC State University, that captures hepatic vascular anatomy and matches physiologic pressures and flow rates.
• In this model, the tumor is represented by a branched vascular structure which simulates HCC tumors down to the arteriole level (18µm).
• Researchers compared in vitro microsphere distribution between the ABK dual-syringe delivery system (DS) and the typical glass Y90 bolus delivery system (BD).
• The ABK DS system delivered a greater number of glass microspheres penetrating distally, and a more uniform distribution compared to BD.

Dr. E. Courtney Henry, Dalhousie University

Global Embolization Symposium & Technologies Annual Meeting 2021

• The poor spatial resolution encountered with Y90 PET and SPECT dosimetry underestimates the true dose heterogeneity following radioembolization.
• Improved estimates of distribution can be obtained with higher resolution dosimetry to accurately quantify dose-response and identify areas at risk of recurrence.
• The steep dose gradients observed with CT-based dosimetry are highly correlated with radioembolized vasculature because it is directly derived from the microspheres implanted distribution.
• The strong positive correlation between radiopaque microspheres and CT-based dosimetry may help physicians with dose-response relationships and improve future patient outcomes.

Dr. Sam Miller, North Carolina State University

Global Embolization Symposium & Technologies Annual Meeting 2021
“Best at GEST” Winner

• Attributes of Y90 distribution in tumors are difficult to observe through in vivo models. This is the first published in vitro model simulating HCC tumors down to the arteriole level (18µm).
• This study compared in vitro microsphere distribution between the ABK dual-syringe delivery system (DS) and a typical glass Y90 bolus delivery system (BD).
• The use of the ABK DS system resulted in a greater number of microspheres penetrating distally compared to BD.
• A more uniform distribution of microspheres was also observed with ABK DS vs BD.
• This study demonstrated that the mode of microsphere delivery affects penetration and uniformity of deposition and may bring a new perspective to Y90 technology development.